| Reaction Details |
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 | Report a problem with these data |
| Target | Replicative DNA helicase |
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| Ligand | BDBM50178999 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_338400 (CHEMBL866546) |
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| IC50 | 18000±n/a nM |
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| Citation |  McKay, GA; Reddy, R; Arhin, F; Belley, A; Lehoux, D; Moeck, G; Sarmiento, I; Parr, TR; Gros, P; Pelletier, J; Far, AR Triaminotriazine DNA helicase inhibitors with antibacterial activity. Bioorg Med Chem Lett16:1286-90 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Replicative DNA helicase |
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| Name: | Replicative DNA helicase |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51573.81 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | ChEMBL_338400 |
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| Residue: | 464 |
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| Sequence: | MNEITSPEQYDLETTALKVPPHSIEAEQAVLGGLMLDNNAWERVSDSVSDGDFYRHDHRL
IFRAIYKLAEANQPIDVVTLSEQLEKEGQLAQVGGLAYLGELAKNIPSVANIKAYAQIIR
ERATLRQLIGISNEIADSAFHPEGRGANEILDEAERKIFEVAEARPKTGGPVGISDILVK
TIDRIDYLFNTTEALTGVSTGFTDLDEKTSGLQPADLIIVAGRPSMGKTTFAMNLVENAV
MRTDKAVLVYSLEMPSDSIVMRMLSSLGRIDQTKVRSGKLDDEDWPRLTSAINLLNDKKL
FIDDTAGISPSEMRARTRRLVREHGDLALIMIDYLQLMQIPGSSGDNRTNEISEISRSLK
ALAKEFNCPVIALSQLNRSLEQRPNKRPVNSDLRESGAIEQDADVIMFVYRDEVYHPETE
FKGVAEIIIGKQRNGPIGTVRLAFIGKYTRFENLAAGMYNFEDE
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| BDBM50178999 |
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| n/a |
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| Name | BDBM50178999 |
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| Synonyms: | 2-(4-(4,6-bis(3,4-difluorophenylamino)-1,3,5-triazin-2-yl)piperazin-1-yl)ethanol | CHEMBL205085 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H21F4N7O |
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| Mol. Mass. | 463.4314 |
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| SMILES | OCCN1CCN(CC1)c1nc(Nc2ccc(F)c(F)c2)nc(Nc2ccc(F)c(F)c2)n1 |
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| Structure | 
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