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TargetCyclin-dependent kinase 7
LigandBDBM50179207
Substrate/Competitorn/a
Meas. Tech.ChEMBL_325230 (CHEMBL861591)
IC50 56700±n/a nM
Citation Ho, CYLudovici, DWMaharoof, USMei, JSechler, JLTuman, RWStrobel, EDAndraka, LYen, HKLeo, GLi, JAlmond, HLu, HDeVine, ATominovich, RMBaker, JEmanuel, SGruninger, RHMiddleton, SAJohnson, DLGalemmo, RA (6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells. J Med Chem48:8163-73 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cyclin-dependent kinase 7
Name:Cyclin-dependent kinase 7
Synonyms:39 kDa protein kinase | CAK | CAK1 | CDK-activating kinase | CDK-activating kinase 1 (CAK) | CDK7 | CDK7_HUMAN | CDKN7 | Cell division protein kinase 7 | Cyclin-Dependent Kinase 7 (CDK7) | Cyclin-dependent kinase 7 (CDK7/cyclin H) | MO15 | P39 Mo15 | STK1 | TFIIH basal transcription factor complex kinase subunit
Type:Enzyme Subunit
Mol. Mass.:39047.01
Organism:Homo sapiens (Human)
Description:n/a
Residue:346
Sequence:
MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTAL
REIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLM
TLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRA
PELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDM
CSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPG
PTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50179207
n/a
NameBDBM50179207
Synonyms:3-fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine | CHEMBL120077 | JNJ-10198409
TypeSmall organic molecule
Emp. Form.C18H16FN3O2
Mol. Mass.325.3369
SMILESCOc1cc2Cc3c(Nc4cccc(F)c4)[nH]nc3-c2cc1OC
Structure
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