Reaction Details |
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Target | Histamine H4 receptor |
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Ligand | BDBM50133005 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_325600 (CHEMBL860282) |
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Ki | 8±n/a nM |
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Citation | Venable, JD; Cai, H; Chai, W; Dvorak, CA; Grice, CA; Jablonowski, JA; Shah, CR; Kwok, AK; Ly, KS; Pio, B; Wei, J; Desai, PJ; Jiang, W; Nguyen, S; Ling, P; Wilson, SJ; Dunford, PJ; Thurmond, RL; Lovenberg, TW; Karlsson, L; Carruthers, NI; Edwards, JP Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem48:8289-98 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histamine H4 receptor |
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Name: | Histamine H4 receptor |
Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 44517.02 |
Organism: | Homo sapiens (Human) |
Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
Residue: | 390 |
Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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BDBM50133005 |
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n/a |
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Name | BDBM50133005 |
Synonyms: | (5-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone | (5-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone | CHEMBL128613 |
Type | Small organic molecule |
Emp. Form. | C14H16BrN3O |
Mol. Mass. | 322.2 |
SMILES | CN1CCN(CC1)C(=O)c1cc2cc(Br)ccc2[nH]1 |
Structure |
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