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TargetHistamine H4 receptor
LigandBDBM50133006
Substrate/Competitorn/a
Meas. Tech.ChEMBL_325600 (CHEMBL860282)
Ki 147±n/a nM
Citation Venable, JDCai, HChai, WDvorak, CAGrice, CAJablonowski, JAShah, CRKwok, AKLy, KSPio, BWei, JDesai, PJJiang, WNguyen, SLing, PWilson, SJDunford, PJThurmond, RLLovenberg, TWKarlsson, LCarruthers, NIEdwards, JP Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists. J Med Chem48:8289-98 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44517.02
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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  Blast E-value cutoff:
BDBM50133006
n/a
NameBDBM50133006
Synonyms:(6-Bromo-1H-indol-2-yl)-(4-methyl-piperazin-1-yl)-methanone | (6-bromo-1H-indol-2-yl)(4-methylpiperazin-1-yl)methanone | CHEMBL338001
TypeSmall organic molecule
Emp. Form.C14H16BrN3O
Mol. Mass.322.2
SMILESCN1CCN(CC1)C(=O)c1cc2ccc(Br)cc2[nH]1
Structure
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