| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50179460 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_339211 (CHEMBL866558) |
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| Ki | 10±n/a nM |
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| Citation |  Tian, X; Chen, X; Gan, L; Hayes, JC; Switzer, AG; Solinsky, MG; Ebetino, FH; Wos, JA; Pinney, BB; Farmer, JA; Crossdoersen, D; Sheldon, RJ Synthesis of Tic-D-Phe Psi[CH2-CH2] isostere and its use in the development of melanocortin receptor agonists. Bioorg Med Chem Lett16:1721-5 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50179460 |
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| n/a |
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| Name | BDBM50179460 |
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| Synonyms: | (R)-2-acetylamino-N-{(R)-1-benzyl-2-[(2S,4R)-4-benzyloxy-2-(3-guanidino-propyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-(4-hydroxy-phenyl)-propionamide | CHEMBL380120 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H44N6O5 |
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| Mol. Mass. | 628.7611 |
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| SMILES | [#6]-[#6](=O)-[#7]-[#6@H](-[#6]-c1ccc(-[#8])cc1)-[#6](=O)-[#7]-[#6@H](-[#6]-c1ccccc1)-[#6](=O)-[#7]-1-[#6]-[#6@@H](-[#6]-[#6@@H]-1-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#8]-[#6]-c1ccccc1 |
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| Structure | 
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