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TargetProstaglandin G/H synthase 2
LigandBDBM50179609
Substrate/Competitorn/a
Meas. Tech.ChEMBL_336080 (CHEMBL865931)
IC50 60±n/a nM
Citation Sakya, SMCheng, HLundy Demello, KMShavnya, AMinich, MLRast, BDutra, JLi, CRafka, RJKoss, DALi, JJaynes, BHZiegler, CBMann, DWPetras, CFSeibel, SBSilvia, AMGeorge, DMHickman, AHaven, MLLynch, MP 5-Heteroatom-substituted pyrazoles as canine COX-2 inhibitors: Part 2. Structure-activity relationship studies of 5-alkylethers and 5-thioethers. Bioorg Med Chem Lett16:1202-6 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin G/H synthase 2
Name:Prostaglandin G/H synthase 2
Synonyms:Cyclooxygenase-2 | Prostaglandin G/H synthase-2
Type:PROTEIN
Mol. Mass.:68982.35
Organism:Canis familiaris
Description:ChEMBL_344386
Residue:604
Sequence:
MLARALVLCAALAVVRAANPCCSHPCQNQGICMSTGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLYLKPTPNTVHYILTHFKGVWNIVNNIPFLRNTIMKYVLTSRSHLIESPPTYNVNY
GYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGKKELPDSKEIVEKFLLRRKFIPDPQGT
NMMFAFFAQHFTHQFFKTDHKRGPAFTKGLGHGVDLNHVYGETLDRQHKLRLFKDGKMKY
QVIDGEVYPPTVKDTQVEMIYPPHVPEHLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIAAEFNTLYHWHPLLPDTLQIDDQEYNFQQFIYNNSILLEHGLTQFVESFSRQIAGRV
AGGRNVPAAVQQVAKASIDQSRQMKYQSLNEYRKRFRLKPYTSFEELTGEKEMAAGLEAL
YGDIDAMELYPALLVEKPRPDAIFGETMVEMGAPFSLKGLMGNPICSPDYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTAFSVQDGQLTKTVTINASSSHSGLDDINPTVLLKER
STEL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50179609
n/a
NameBDBM50179609
Synonyms:1-(5-(methylsulfonyl)pyridin-2-yl)-5-(phenylthio)-3-(trifluoromethyl)-1H-pyrazole-4-carbonitrile | CHEMBL381158
TypeSmall organic molecule
Emp. Form.C17H11F3N4O2S2
Mol. Mass.424.42
SMILESCS(=O)(=O)c1ccc(nc1)-n1nc(c(C#N)c1Sc1ccccc1)C(F)(F)F
Structure
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