| Reaction Details |
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 | Report a problem with these data |
| Target | Aromatase |
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| Ligand | BDBM50179635 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_335115 (CHEMBL859206) |
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| IC50 | 9±n/a nM |
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| Citation |  Lézé, MP; Le Borgne, M; Pinson, P; Palusczak, A; Duflos, M; Le Baut, G; Hartmann, RW Synthesis and biological evaluation of 5-[(aryl)(1H-imidazol-1-yl)methyl]-1H-indoles: potent and selective aromatase inhibitors. Bioorg Med Chem Lett16:1134-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aromatase |
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| Name: | Aromatase |
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| Synonyms: | ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM |
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| Type: | Enzyme |
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| Mol. Mass.: | 57888.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11511 |
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| Residue: | 503 |
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| Sequence: | MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLI
SHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKL
GLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTN
ESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWL
YKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCI
LEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFI
YESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAK
NVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLH
PDETKNMLEMIFTPRNSDRCLEH
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| BDBM50179635 |
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| n/a |
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| Name | BDBM50179635 |
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| Synonyms: | (+)-5-[(4-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-indole | (-)-5-[(4-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-indole | 5-[(4-chlorophenyl)(1H-imidazol-1-yl)methyl]-1H-indole | CHEMBL204039 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14ClN3 |
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| Mol. Mass. | 307.777 |
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| SMILES | Clc1ccc(cc1)C(c1ccc2[nH]ccc2c1)n1ccnc1 |
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| Structure | 
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