| Reaction Details |
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 | Report a problem with these data |
| Target | 17-beta-hydroxysteroid dehydrogenase type 3 |
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| Ligand | BDBM50179959 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_340362 (CHEMBL864403) |
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| IC50 | 170±n/a nM |
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| Citation |  Fink, BE; Gavai, AV; Tokarski, JS; Goyal, B; Misra, R; Xiao, HY; Kimball, SD; Han, WC; Norris, D; Spires, TE; You, D; Gottardis, MM; Lorenzi, MV; Vite, GD Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3. Bioorg Med Chem Lett16:1532-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 17-beta-hydroxysteroid dehydrogenase type 3 |
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| Name: | 17-beta-hydroxysteroid dehydrogenase type 3 |
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| Synonyms: | 17-beta-hydroxysteroid dehydrogenase type 3 | DHB3_HUMAN | EDH17B3 | Estradiol 17-beta-dehydrogenase 3 | HSD17B3 | SDR12C2 |
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| Type: | Enzyme |
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| Mol. Mass.: | 34525.39 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P37058 |
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| Residue: | 310 |
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| Sequence: | MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL
AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI
LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN
TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
AYLKLNTKVR
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| BDBM50179959 |
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| n/a |
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| Name | BDBM50179959 |
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| Synonyms: | 1-(2-chloro-6,11-dihydro-5-thia-12-aza-dibenzo[a,e]cycloocten-12-yl)-ethanone | CHEMBL202967 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H14ClNOS |
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| Mol. Mass. | 303.806 |
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| SMILES | CC(=O)N1Cc2ccccc2CSc2ccc(Cl)cc12 |
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| Structure | 
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