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Target17-beta-hydroxysteroid dehydrogenase type 3
LigandBDBM50179940
Substrate/Competitorn/a
Meas. Tech.ChEMBL_340361
IC50 0.7±n/a nM
Citation Fink BEGavai AVTokarski JSGoyal BMisra RXiao HYKimball SDHan WCNorris DSpires TEYou DGottardis MMLorenzi MVVite GD Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17beta-hydroxysteroid dehydrogenase type 3. Bioorg Med Chem Lett 16:1532-6 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
17-beta-hydroxysteroid dehydrogenase type 3
Name:Estradiol 17-beta-dehydrogenase 3
Synonyms:Estradiol 17-beta-dehydrogenase 3
Type:Enzyme
Mol. Mass.:34525.39
Organism:Homo sapiens (Human)
Description:P37058
Residue:310
Sequence:
MGDVLEQFFILTGLLVCLACLAKCVRFSRCVLLNYWKVLPKSFLRSMGQWAVITGAGDGI
GKAYSFELAKRGLNVVLISRTLEKLEAIATEIERTTGRSVKIIQADFTKDDIYEHIKEKL
AGLEIGILVNNVGMLPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLI
LNISSGIALFPWPLYSMYSASKAFVCAFSKALQEEYKAKEVIIQVLTPYAVSTAMTKYLN
TNVITKTADEFVKESLNYVTIGGETCGCLAHEILAGFLSLIPAWAFYSGAFQRLLLTHYV
AYLKLNTKVR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50179940
n/a
NameBDBM50179940
Synonyms:2-(5-acetyl-2-bromo-5,6,11,12-tetrahydro-dibenzo[b,f]azocin-8-yl)-benzoic acid methyl ester | CHEMBL204882
TypeSmall organic molecule
Emp. Form.C25H22BrNO3
Mol. Mass.464.351
SMILESCOC(=O)c1ccccc1-c1ccc2CCc3cc(Br)ccc3N(Cc2c1)C(C)=O
Structure
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