| Reaction Details |
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 | Report a problem with these data |
| Target | DNA topoisomerase 4 subunit A |
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| Ligand | BDBM50045000 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_329797 (CHEMBL854373) |
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| IC50 | 3500±n/a nM |
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| Citation |  Wiles, JA; Hashimoto, A; Thanassi, JA; Cheng, J; Incarvito, CD; Deshpande, M; Pucci, MJ; Bradbury, BJ Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents. J Med Chem49:39-42 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA topoisomerase 4 subunit A |
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| Name: | DNA topoisomerase 4 subunit A |
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| Synonyms: | PARC_STAAU | Topoisomerase IV subunit A | grlA | parC |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91040.14 |
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| Organism: | Staphylococcus aureus |
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| Description: | ChEMBL_340188 |
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| Residue: | 800 |
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| Sequence: | MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNF
RKSAKTVGDVIGQYHPHGDFSVYKAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYT
EAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIP
PHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR
SKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIA
IELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVAN
RTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEVFEFTEEQAEAI
VMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL
SLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKH
QEVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFN
TDAFYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQLITVITNK
GMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKI
LQVAKRAQRGITLLKELKKNPHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYT
NGSFIVDTDDFGEVIDMYIS
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| BDBM50045000 |
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| n/a |
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| Name | BDBM50045000 |
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| Synonyms: | (NFLX)1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid | (norfloxacin)1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid | 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4,4a,8a-tetrahydro-quinoline-3-carboxylic acid (norfloxacin) | 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid | 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid (Norfloxacin) | 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid(1-norfloxacin) | 1-Ethyl-6-fluoro-4-oxo-7-piperazin-1-yl-1,4-dihydro-quinoline-3-carboxylic acid(Norfloxacin) | 1-ethyl-6-fluoro-4-oxo-7-(piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid | 1-ethyl-6-fluoro-7-hexahydro-1-pyrazinyl-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid | CHEMBL9 | Chibroxin | MK-366 | NORFLOXACIN | Noroxin |
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| Type | Small organic molecule |
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| Emp. Form. | C16H18FN3O3 |
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| Mol. Mass. | 319.3308 |
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| SMILES | CCn1cc(C(O)=O)c(=O)c2cc(F)c(cc12)N1CCNCC1 |
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| Structure | 
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