Reaction Details | |||
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Target | Protein c-Fos/Transcription factor Jun | ||
Ligand | BDBM50180048 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_329857 (CHEMBL870579) | ||
IC50 | 13300±n/a nM | ||
Citation | Tsuchida, K; Chaki, H; Takakura, T; Kotsubo, H; Tanaka, T; Aikawa, Y; Shiozawa, S; Hirono, S Discovery of nonpeptidic small-molecule AP-1 inhibitors: lead hopping based on a three-dimensional pharmacophore model. J Med Chem49:80-91 (2006) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein c-Fos/Transcription factor Jun | |||
Name: | Protein c-Fos/Transcription factor Jun | ||
Synonyms: | Proto-oncogene c-JUN/protein c-fos | Transcription factor AP1 | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of EBI is 305353 | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Transcription factor Jun | ||
Synonyms: | AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39 | ||
Type: | n/a | ||
Mol. Mass.: | 35683.24 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P05412 | ||
Residue: | 331 | ||
Sequence: |
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Component 2 | |||
Name: | Protein c-Fos | ||
Synonyms: | FOS | FOS_HUMAN | G0S7 | Transcription factor AP1 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 40679.34 | ||
Organism: | Homo sapiens (Human) | ||
Description: | EBI_100167 | ||
Residue: | 380 | ||
Sequence: |
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BDBM50180048 | |||
n/a | |||
Name | BDBM50180048 | ||
Synonyms: | (R)-8-(3-methylbutylidene)-4-(5-methylhexanoyl)-1-thia-4-aza-spiro[4.5]decane-3-carboxylic acid | CHEMBL426477 | ||
Type | Small organic molecule | ||
Emp. Form. | C21H35NO3S | ||
Mol. Mass. | 381.573 | ||
SMILES | CC(C)CCCC(=O)N1[C@@H](CSC11CCC(CC1)=CCC(C)C)C(O)=O |wU:9.24,(8.93,-9.16,;7.84,-8.07,;8.25,-6.58,;6.35,-8.46,;5.27,-7.36,;5.68,-5.88,;4.6,-4.78,;3.11,-5.17,;5,-3.29,;6.45,-2.75,;6.37,-1.21,;4.89,-.81,;4.04,-2.09,;3.34,-3.46,;1.8,-3.53,;.97,-2.23,;1.68,-.87,;3.22,-.8,;-.57,-2.31,;-1.4,-1.01,;-2.94,-1.08,;-3.77,.22,;-3.65,-2.45,;7.73,-3.6,;9.11,-2.91,;7.64,-5.14,)| | ||
Structure |