| Reaction Details |
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 | Report a problem with these data |
| Target | Chromaffin granule amine transporter |
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| Ligand | BDBM50180054 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_329947 (CHEMBL868808) |
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| Ki | >10000±n/a nM |
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| Citation |  Kumar, JS; Majo, VJ; Hsiung, SC; Millak, MS; Liu, KP; Tamir, H; Prabhakaran, J; Simpson, NR; Van Heertum, RL; Mann, JJ; Parsey, RV Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand. J Med Chem49:125-34 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chromaffin granule amine transporter |
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| Name: | Chromaffin granule amine transporter |
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| Synonyms: | Chromaffin granule amine transporter | SLC18A1 | Solute carrier family 18 member 1 | VAT1 | VMAT1 | VMAT1_HUMAN | Vesicular amine transporter 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56252.64 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_329947 |
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| Residue: | 525 |
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| Sequence: | MLRTILDAPQRLLKEGRASRQLVLVVVFVALLLDNMLFTVVVPIVPTFLYDMEFKEVNSS
LHLGHAGSSPHALASPAFSTIFSFFNNNTVAVEESVPSGIAWMNDTASTIPPPATEAISA
HKNNCLQGTGFLEEEITRVGVLFASKAVMQLLVNPFVGPLTNRIGYHIPMFAGFVIMFLS
TVMFAFSGTYTLLFVARTLQGIGSSFSSVAGLGMLASVYTDDHERGRAMGTALGGLALGL
LVGAPFGSVMYEFVGKSAPFLILAFLALLDGALQLCILQPSKVSPESAKGTPLFMLLKDP
YILVAAGSICFANMGVAILEPTLPIWMMQTMCSPKWQLGLAFLPASVSYLIGTNLFGVLA
NKMGRWLCSLIGMLVVGTSLLCVPLAHNIFGLIGPNAGLGLAIGMVDSSMMPIMGHLVDL
RHTSVYGSVYAIADVAFCMGFAIGPSTGGAIVKAIGFPWLMVITGVINIVYAPLCYYLRS
PPAKEEKLAILSQDCPMETRMYATQKPTKEFPLGEDSDEEPDHEE
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| BDBM50180054 |
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| n/a |
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| Name | BDBM50180054 |
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| Synonyms: | CHEMBL199824 | [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin-1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione |
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| Type | Small organic molecule |
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| Emp. Form. | C23H29N5O3 |
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| Mol. Mass. | 423.5081 |
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| SMILES | COc1ccc2cccc(N3CCN(CCCCn4ncc(=O)n(C)c4=O)CC3)c2c1 |
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| Structure | 
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