| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Phosphotransferase |
|---|
| Ligand | BDBM50173790 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_330068 (CHEMBL865780) |
|---|
| IC50 | 3470±n/a nM |
|---|
| Citation |  Hudock, MP; Sanz-Rodríguez, CE; Song, Y; Chan, JM; Zhang, Y; Odeh, S; Kosztowski, T; Leon-Rossell, A; Concepción, JL; Yardley, V; Croft, SL; Urbina, JA; Oldfield, E Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. J Med Chem49:215-23 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Phosphotransferase |
|---|
| Name: | Phosphotransferase |
|---|
| Synonyms: | Hexokinase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 52180.94 |
|---|
| Organism: | Trypanosoma cruzi |
|---|
| Description: | ChEMBL_330068 |
|---|
| Residue: | 471 |
|---|
| Sequence: | MSARLNNLLQHIAVKDKDSDTMRHLKQRMALASLANQFTVGKDHLKQLMLYMVHQMIEGL
EGRESTLRMLPSYVYKTDPSKATGVFYALDLGGTNFRVLRVTCKEGRVADRVDAKFVIPQ
QALQGTAEDLFGFIAQSVKKMMEQKAPEDLNRTVPLGFTFSFPTEQKGVDHGFLIKWTKG
FSTRGVEGKDVVELLQKALKRMEVKVKVVALCNDTVGTLITNYFFDPDTQVGVIIGTGSN
ACYFEDAYAVTKEPSVAARGTTQTPINMECGNFDSKYKFVLPVTAYDEAMDAVTPNRNFQ
TQEKMVSGMYLGEISRRMIAHLAELHCLPSALASKMAKPWSFETKFMGMISADRMPGLQF
TRQVFQELFQVDVTDVADLHVIRDVCCLVRGRAAQISAMFCSAPLVKTRKEGRATVAIDG
SVFEKTPSFRRLLQQNMNAILGPGCDVTTALARDGSGIGAAFISALVVNDK
|
|
|
|---|
| BDBM50173790 |
|---|
| n/a |
|---|
| Name | BDBM50173790 |
|---|
| Synonyms: | 2-(biphenyl-3-ylamino)ethane-1,1-diyldiphosphonic acid | BPH-312 | CHEMBL381465 | [2-(Biphenyl-3-ylamino)-1-phosphono-ethyl]-phosphonic acid |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H17NO6P2 |
|---|
| Mol. Mass. | 357.2354 |
|---|
| SMILES | OP(O)(=O)C(CNc1cccc(c1)-c1ccccc1)P(O)(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
