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TargetPolyprenyl synthetase family protein
LigandBDBM12576
Substrate/Competitorn/a
Meas. Tech.ChEMBL_330072 (CHEMBL858875)
IC50 170±n/a nM
Citation Hudock, MPSanz-Rodríguez, CESong, YChan, JMZhang, YOdeh, SKosztowski, TLeon-Rossell, AConcepción, JLYardley, VCroft, SLUrbina, JAOldfield, E Inhibition of Trypanosoma cruzi hexokinase by bisphosphonates. J Med Chem49:215-23 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Polyprenyl synthetase family protein
Name:Polyprenyl synthetase family protein
Synonyms:Farnesyl diphosphate synthase | Farnesyl pyrophosphate synthase
Type:PROTEIN
Mol. Mass.:41078.35
Organism:Plasmodium falciparum (isolate 3D7)
Description:ChEMBL_330072
Residue:362
Sequence:
MAHMERFQKVYEEVQEFLLGDAEKRFEMDVHRKGYLKSMMDTTCLGGKYNRGLCVVDVAE
AMAKDTKMDAAAMERVLHDACVCGWMIEMLQAHFLVEDDIMDHSKTRRGKPCWYLHPGVT
TQVAINDGLILLAWATQMALHYFADRPFLAEVLRVFHDVDLTTTIGQLYDVTSMVDSAKL
DANVAHANTTDYIEYTPFNHRRIVVYKTAYYTYWLPLVMGLLVSGTVEKVDKEATHKVAM
VMGEYFQVQDDVMDCFTPPEKLGKIGTDIEDAKCSWLAVTFLTTAPAEKVAEFKANYGST
DPAKVAVIKQLYTEQNLLARFEEYEKAVVAEIEQLIAALEAQNTAFAASVKVLWSKTYKR
QK
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  Blast E-value cutoff:
BDBM12576
n/a
NameBDBM12576
Synonyms:Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound 64 | RIS | Risdronate | US11279719, Example Risedronic acid RIS | [1-hydroxy-1-phosphono-2-(pyridin-3-yl)ethyl]phosphonic acid
TypeSmall organic molecule
Emp. Form.C7H11NO7P2
Mol. Mass.283.1123
SMILESOC(Cc1cccnc1)(P(O)(O)=O)P(O)(O)=O
Structure
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