Reaction Details |
| Report a problem with these data |
Target | Transient receptor potential cation channel subfamily V member 1 |
---|
Ligand | BDBM50212312 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_326997 (CHEMBL863529) |
---|
IC50 | 105±n/a nM |
---|
Citation | Culshaw, AJ; Bevan, S; Christiansen, M; Copp, P; Davis, A; Davis, C; Dyson, A; Dziadulewicz, EK; Edwards, L; Eggelte, H; Fox, A; Gentry, C; Groarke, A; Hallett, A; Hart, TW; Hughes, GA; Knights, S; Kotsonis, P; Lee, W; Lyothier, I; McBryde, A; McIntyre, P; Paloumbis, G; Panesar, M; Patel, S; Seiler, MP; Yaqoob, M; Zimmermann, K Identification and biological characterization of 6-aryl-7-isopropylquinazolinones as novel TRPV1 antagonists that are effective in models of chronic pain. J Med Chem49:471-4 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Transient receptor potential cation channel subfamily V member 1 |
---|
Name: | Transient receptor potential cation channel subfamily V member 1 |
Synonyms: | Capsaicin receptor | OTRPC1 | TRPV1_RAT | Transient receptor potential cation channel subfamily V member 1 (TRPV1) | Trpv1 | Vanilloid Receptor 1 (TRPV1, VR1) | Vanilloid VR1 | Vanilloid receptor | Vanilloid receptor 1 (VRI/TRPV1) | Vanilloid receptor type 1-like | Vanilloid receptor type 1-like (TrpV1/Vr1) | Vr1 | Vr1l | osm-9-like TRP channel 1 |
Type: | Transient Receptor |
Mol. Mass.: | 94956.12 |
Organism: | Rattus norvegicus (rat) |
Description: | O35433 |
Residue: | 838 |
Sequence: | MEQRASLDSEESESPPQENSCLDPPDRDPNCKPPPVKPHIFTTRSRTRLFGKGDSEEASP
LDCPYEEGGLASCPIITVSSVLTIQRPGDGPASVRPSSQDSVSAGEKPPRLYDRRSIFDA
VAQSNCQELESLLPFLQRSKKRLTDSEFKDPETGKTCLLKAMLNLHNGQNDTIALLLDVA
RKTDSLKQFVNASYTDSYYKGQTALHIAIERRNMTLVTLLVENGADVQAAANGDFFKKTK
GRPGFYFGELPLSLAACTNQLAIVKFLLQNSWQPADISARDSVGNTVLHALVEVADNTVD
NTKFVTSMYNEILILGAKLHPTLKLEEITNRKGLTPLALAASSGKIGVLAYILQREIHEP
ECRHLSRKFTEWAYGPVHSSLYDLSCIDTCEKNSVLEVIAYSSSETPNRHDMLLVEPLNR
LLQDKWDRFVKRIFYFNFFVYCLYMIIFTAAAYYRPVEGLPPYKLKNTVGDYFRVTGEIL
SVSGGVYFFFRGIQYFLQRRPSLKSLFVDSYSEILFFVQSLFMLVSVVLYFSQRKEYVAS
MVFSLAMGWTNMLYYTRGFQQMGIYAVMIEKMILRDLCRFMFVYLVFLFGFSTAVVTLIE
DGKNNSLPMESTPHKCRGSACKPGNSYNSLYSTCLELFKFTIGMGDLEFTENYDFKAVFI
ILLLAYVILTYILLLNMLIALMGETVNKIAQESKNIWKLQRAITILDTEKSFLKCMRKAF
RSGKLLQVGFTPDGKDDYRWCFRVDEVNWTTWNTNVGIINEDPGNCEGVKRTLSFSLRSG
RVSGRNWKNFALVPLLRDASTRDRHATQQEEVQLKHYTGSLKPEDAEVFKDSMVPGEK
|
|
|
BDBM50212312 |
---|
n/a |
---|
Name | BDBM50212312 |
Synonyms: | 6(4-chloro-3-cyclopropylmethoxy-phenyl)-7-isopropyl-2-methyl-3H-quinazolin-4-one | 6-(4-chloro-3-(cyclopropylmethoxy)phenyl)-7-isopropyl-2-methylquinazolin-4(3H)-one | CHEMBL436839 |
Type | Small organic molecule |
Emp. Form. | C22H23ClN2O2 |
Mol. Mass. | 382.883 |
SMILES | CC(C)c1cc2nc(C)[nH]c(=O)c2cc1-c1ccc(Cl)c(OCC2CC2)c1 |
Structure |
|