Reaction Details |
| Report a problem with these data |
Target | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
---|
Ligand | BDBM50180777 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_327201 (CHEMBL859562) |
---|
Ki | 0.700000±n/a nM |
---|
Citation | Lang, M; De Pol, S; Baldauf, C; Hofmann, HJ; Reiser, O; Beck-Sickinger, AG Identification of the key residue of calcitonin gene related peptide (CGRP) 27-37 to obtain antagonists with picomolar affinity at the CGRP receptor. J Med Chem49:616-24 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
---|
Name: | Calcitonin gene-related peptide type 1 receptor/Receptor activity-modifying protein 1 |
Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 |
Type: | n/a |
Mol. Mass.: | n/a |
Description: | ASSAY_ID of EBI is 327200 |
Components: | This complex has 2 components. |
Component 1 |
Name: | Calcitonin gene-related peptide type 1 receptor |
Synonyms: | Adrenomedullin receptor AM1; CALCRL/RAMP2 | CALCRL | CALRL_HUMAN | CGRP type 1 receptor | CGRP type 1 receptor mRNA | CGRPR | Calcitonin gene-related peptide (CGRP) receptor | Calcitonin gene-related peptide 1 (CGRP) | Calcitonin receptor-like receptor | Calcitonin receptor-like receptor (CLR) | Human CL receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 52980.45 |
Organism: | Homo sapiens (Human) |
Description: | Q16602 |
Residue: | 461 |
Sequence: | MEKKCTLYFLVLLPFFMILVTAELEESPEDSIQLGVTRNKIMTAQYECYQKIMQDPIQQA
EGVYCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICDQDGNWFRHPASNRT
WTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNL
FFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTL
IVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICA
ALLVNLFFLLNIVRVLITKLKVTHQAESNLYMKAVRATLILVPLLGIEFVLIPWRPEGKI
AEEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQYKIQFGNSFSNSEALRSAS
YTVSTISDGPGYSHDCPSEHLNGKSIHDIENVLLKPENLYN
|
|
|
Component 2 |
Name: | Receptor activity-modifying protein 1 |
Synonyms: | Calcitonin-gene-related peptide receptor, CALCRL/RAMP1 | RAMP1 | RAMP1_HUMAN |
Type: | PROTEIN |
Mol. Mass.: | 16992.80 |
Organism: | Homo sapiens (Human) |
Description: | EBI_100673 |
Residue: | 148 |
Sequence: | MARALCRLPRRGLWLLLAHHLFMTTACQEANYGALLRELCLTQFQVDMEAVGETLWCDWG
RTIRSYRELADCTWHMAEKLGCFWPNAEVDRFFLAVHGRYFRSCPISGRAVRDPPGSILY
PFIVVPITVTLLVTALVVWQSKRTEGIV
|
|
|
BDBM50180777 |
---|
n/a |
---|
Name | BDBM50180777 |
Synonyms: | CHEMBL427759 | FV((1R,2R,3R)-beta-aminocyclopropane carboxylic acid)TDVGPFAF |
Type | Small organic molecule |
Emp. Form. | C61H81N11O17 |
Mol. Mass. | 1240.3593 |
SMILES | COC(=O)[C@H]1[C@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccccc2)C(C)C)[C@@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(O)=O |
Structure |
|