Reaction Details |
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Target | Interstitial collagenase |
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Ligand | BDBM50181002 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_339180 (CHEMBL867736) |
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IC50 | 1±n/a nM |
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Citation | Levin, JI; Chen, JM; Laakso, LM; Du, M; Schmid, J; Xu, W; Cummons, T; Xu, J; Jin, G; Barone, D; Skotnicki, JS Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg Med Chem Lett16:1605-9 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interstitial collagenase |
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Name: | Interstitial collagenase |
Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
Type: | Enzyme |
Mol. Mass.: | 54010.26 |
Organism: | Homo sapiens (Human) |
Description: | P03956 |
Residue: | 469 |
Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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BDBM50181002 |
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n/a |
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Name | BDBM50181002 |
Synonyms: | (S)-N-hydroxy-2,2-dimethyl-4-(4-(prop-2-ynyloxy)phenylsulfonyl)thiomorpholine-3-carboxamide | CHEMBL207776 |
Type | Small organic molecule |
Emp. Form. | C16H20N2O5S2 |
Mol. Mass. | 384.47 |
SMILES | CC1(C)SCCN([C@H]1C(=O)NO)S(=O)(=O)c1ccc(OCC#C)cc1 |
Structure |
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