Reaction Details |
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Target | Kinesin-like protein KIF11 |
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Ligand | BDBM50181137 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_345008 (CHEMBL868957) |
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IC50 | 1.3±n/a nM |
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Citation | Garbaccio, RM; Fraley, ME; Tasber, ES; Olson, CM; Hoffman, WF; Arrington, KL; Torrent, M; Buser, CA; Walsh, ES; Hamilton, K; Schaber, MD; Fernandes, C; Lobell, RB; Tao, W; South, VJ; Yan, Y; Kuo, LC; Prueksaritanont, T; Slaughter, DE; Shu, C; Heimbrook, DC; Kohl, NE; Huber, HE; Hartman, GD Kinesin spindle protein (KSP) inhibitors. Part 3: synthesis and evaluation of phenolic 2,4-diaryl-2,5-dihydropyrroles with reduced hERG binding and employment of a phosphate prodrug strategy for aqueous solubility. Bioorg Med Chem Lett16:1780-3 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Kinesin-like protein KIF11 |
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Name: | Kinesin-like protein KIF11 |
Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Kinesin Spindle Protein Eg5 | Kinesin-like protein 1 | TRIP5 | kinesin spindle protein |
Type: | PROTEIN |
Mol. Mass.: | 119138.97 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_1457426 |
Residue: | 1056 |
Sequence: | MASQPNSSAKKKEEKGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADK
SSRKTYTFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERS
PNEEYTWEEDPLAGIIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSE
RLQMFDDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFS
VTIHMKETTIDGEELVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVIT
ALVERTPHVPYRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKLTKKALIKEYTEEIERLKRDLAAAREKNGVYISEENFRVMSGKLTVQEEQIV
ELIEKIGAVEEELNRVTELFMDNKNELDQCKSDLQNKTQELETTQKHLQETKLQLVKEEY
ITSALESTEEKLHDAASKLLNTVEETTKDVSGLHSKLDRKKAVDQHNAEAQDIFGKNLNS
LFNNMEELIKDGSSKQKAMLEVHKTLFGNLLSSSVSALDTITTVALGSLTSIPENVSTHV
SQIFNMILKEQSLAAESKTVLQELINVLKTDLLSSLEMILSPTVVSILKINSQLKHIFKT
SLTVADKIEDQKKELDGFLSILCNNLHELQENTICSLVESQKQCGNLTEDLKTIKQTHSQ
ELCKLMNLWTERFCALEEKCENIQKPLSSVQENIQQKSKDIVNKMTFHSQKFCADSDGFS
QELRNFNQEGTKLVEESVKHSDKLNGNLEKISQETEQRCESLNTRTVYFSEQWVSSLNER
EQELHNLLEVVSQCCEASSSDITEKSDGRKAAHEKQHNIFLDQMTIDEDKLIAQNLELNE
TIKIGLTKLNCFLEQDLKLDIPTGTTPQRKSYLYPSTLVRTEPREHLLDQLKRKQPELLM
MLNCSENNKEETIPDVDVEEAVLGQYTEEPLSQEPSVDAGVDCSSIGGVPFFQHKKSHGK
DKENRGINTLERSKVEETTEHLVTKSRLPLRAQINL
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BDBM50181137 |
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n/a |
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Name | BDBM50181137 |
Synonyms: | (S)-1-((S)-4-(2,5-difluorophenyl)-2-(3-hydroxyphenyl)-2H-pyrrol-1(5H)-yl)-2-hydroxy-3,3-dimethylbutan-1-one | CHEMBL262736 |
Type | Small organic molecule |
Emp. Form. | C22H23F2NO3 |
Mol. Mass. | 387.4197 |
SMILES | CC(C)(C)[C@H](O)C(=O)N1CC(=C[C@H]1c1cccc(O)c1)c1cc(F)ccc1F |c:10| |
Structure |
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