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TargetGrowth hormone secretagogue receptor type 1
LigandBDBM50181180
Substrate/Competitorn/a
Meas. Tech.ChEMBL_345663 (CHEMBL859713)
IC50 3±n/a nM
Citation Liu, BLiu, MXin, ZZhao, HSerby, MDKosogof, CNelson, LTSzczepankiewicz, BGKaszubska, WSchaefer, VGFalls, HDLin, CWCollins, CASham, HLLiu, G Optimization of 2,4-diaminopyrimidines as GHS-R antagonists: side chain exploration. Bioorg Med Chem Lett16:1864-8 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Growth hormone secretagogue receptor type 1
Name:Growth hormone secretagogue receptor type 1
Synonyms:GH-releasing peptide receptor | GHRP | GHS-R | GHSR | GHSR_HUMAN | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | Ghrelin receptor | Ghrelin receptor 1a (GHS-R1a)
Type:Receptor
Mol. Mass.:41334.57
Organism:Homo sapiens (Human)
Description:Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAG
NLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQ
FVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFV
LVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLW
RRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQI
SQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWT
ESSINT
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  Blast E-value cutoff:
BDBM50181180
n/a
NameBDBM50181180
Synonyms:CHEMBL377514 | N-(3,5-dimethylbenzyl)-3-(5-(4-(4-(methylsulfonyl)benzylamino)phenyl)-2,6-diaminopyrimidin-4-yl)propanamide
TypeSmall organic molecule
Emp. Form.C30H34N6O3S
Mol. Mass.558.694
SMILESCc1cc(C)cc(CNC(=O)CCc2nc(N)nc(N)c2-c2ccc(NCc3ccc(cc3)S(C)(=O)=O)cc2)c1
Structure
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