| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin E2 receptor EP4 subtype |
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| Ligand | BDBM50181289 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_345142 (CHEMBL869627) |
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| IC50 | 17±n/a nM |
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| Citation |  Cameron, KO; Lefker, BA; Chu-Moyer, MY; Crawford, DT; Jardine, PD; DeNinno, SL; Gilbert, S; Grasser, WA; Ke, H; Lu, B; Owen, TA; Paralkar, VM; Qi, H; Scott, DO; Thompson, DD; Tjoa, CM; Zawistoski, MP Discovery of highly selective EP4 receptor agonists that stimulate new bone formation and restore bone mass in ovariectomized rats. Bioorg Med Chem Lett16:1799-802 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin E2 receptor EP4 subtype |
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| Name: | Prostaglandin E2 receptor EP4 subtype |
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| Synonyms: | PE2R4_RAT | Prostanoid EP4 receptor | Ptger4 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 53381.95 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1290039 |
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| Residue: | 488 |
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| Sequence: | MSIPGVNASFSSTPERLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGDQALCDYSTFILLFFGLSGLSIICAMSIERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGRSERQYPGTWCFIDWTTNVTA
YAAFSYMYAGFSSFLILATVLCNVLVCGALLRMLRQFMRRTSLGTEQHHAAAAAAVASVA
CRGHAAASPALQRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFINQL
YQPSVVKDISRNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSGRD
GSAQHCSESRRTSSAMSGHSRSFLSRELREISSTSHTLLYLPDLTESSLGGKNLLPGTHG
MGLTQADTTSLRTLRISETSDSSQGQDSESVLLVDEVSGSQREEPASKGNSLQVTFPSET
LKLSEKCI
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| BDBM50181289 |
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| n/a |
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| Name | BDBM50181289 |
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| Synonyms: | 5-(3-((S)-2-(4-(3-fluorophenyl)-3-hydroxybutyl)-5-oxopyrrolidin-1-yl)propyl)thiophene-2-carboxylic acid | CHEMBL378968 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H26FNO4S |
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| Mol. Mass. | 419.51 |
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| SMILES | OC(CC[C@H]1CCC(=O)N1CCCc1ccc(s1)C(O)=O)Cc1cccc(F)c1 |
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| Structure | 
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