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TargetFructose-1,6-bisphosphatase 1 (FBPase)
LigandBDBM50181324
Substrate/Competitorn/a
Meas. Tech.ChEMBL_345422
IC50 570±n/a nM
Citation Lai CGum RJDaly MFry EHHutchins CAbad-Zapatero Cvon Geldern TW Benzoxazole benzenesulfonamides as allosteric inhibitors of fructose-1,6-bisphosphatase. Bioorg Med Chem Lett 16:1807-10 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Fructose-1,6-bisphosphatase 1 (FBPase)
Name:Fructose-1,6-bisphosphatase
Synonyms:D-fructose-1,6-bisphosphate 1-phosphohydrolase 1 | FBPase 1 | Fructose-1,6-bisphosphatase | Fructose-1,6-bisphosphatase 1
Type:Protein
Mol. Mass.:36843.58
Organism:Homo sapiens (Human)
Description:Liver FBPase (P09467)
Residue:338
Sequence:
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGI
AGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDP
LDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDC
GVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAP
YGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGK
EAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50181324
n/a
NameBDBM50181324
Synonyms:CHEMBL205792 | N-(7-(3-aminophenyl)-5-methoxybenzo[d]oxazol-2-yl)-2,5-dichlorobenzenesulfonamide | N-[7-(3-AMINOPHENYL)-5-METHOXY-1,3-BENZOXAZOL-2-YL]-2,5-DICHLOROBENZENESULFONAMIDE
TypeSmall organic molecule
Emp. Form.C20H15Cl2N3O4S
Mol. Mass.464.322
SMILESCOc1cc(-c2cccc(N)c2)c2oc(NS(=O)(=O)c3cc(Cl)ccc3Cl)nc2c1
Structure
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