Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50181652 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_330651 (CHEMBL867029) |
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IC50 | 289±n/a nM |
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Citation | Tedesco, R; Shaw, AN; Bambal, R; Chai, D; Concha, NO; Darcy, MG; Dhanak, D; Fitch, DM; Gates, A; Gerhardt, WG; Halegoua, DL; Han, C; Hofmann, GA; Johnston, VK; Kaura, AC; Liu, N; Keenan, RM; Lin-Goerke, J; Sarisky, RT; Wiggall, KJ; Zimmerman, MN; Duffy, KJ 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem49:971-83 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50181652 |
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n/a |
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Name | BDBM50181652 |
Synonyms: | 3-(1,1-dioxo-2H-1,2,4-benzothiadiazin-3-yl)-4-hydroxy-1-(3-methyl-2-buten-1-yl)-1H-quinolin-2-one | CHEMBL381218 |
Type | Small organic molecule |
Emp. Form. | C21H19N3O4S |
Mol. Mass. | 409.458 |
SMILES | [#6]\[#6](-[#6])=[#6]\[#6]-n1c2ccccc2c(-[#8])c(-[#6]-2=[#7]-c3ccccc3S(=O)(=O)[#7]-2)c1=O |t:16| |
Structure |
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