Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHepatitis C virus NS5B RNA-dependent RNA polymerase
LigandBDBM50181559
Substrate/Competitorn/a
Meas. Tech.ChEMBL_330654
IC50 10±n/a nM
Citation Tedesco RShaw ANBambal RChai DConcha NODarcy MGDhanak DFitch DMGates AGerhardt WGHalegoua DLHan CHofmann GAJohnston VKKaura ACLiu NKeenan RMLin-Goerke JSarisky RTWiggall KJZimmerman MNDuffy KJ 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem 49:971-83 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hepatitis C virus NS5B RNA-dependent RNA polymerase
Name:Hepatitis C virus NS5B RNA-dependent RNA polymerase
Synonyms:NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50181559
n/a
NameBDBM50181559
Synonyms:1-(2-CYCLOPROPYLETHYL)-3-(1,1-DIOXIDO-2H-1,2,4-BENZOTHIADIAZIN-3-YL)-6-FLUORO-4-HYDROXYQUINOLIN-2(1H)-ONE | 1-(2-Cyclopropyl-ethyl)-3-(1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-3-yl)-6-fluoro-4-hydroxy-1H-quinolin-2-one | 1-(2-cyclopropylethyl)-3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]-thiadiazin-3-yl) -6-fluoro-4-hydroxy-1-quinolin-2-one | CHEMBL372357
TypeSmall organic molecule
Emp. Form.C21H18FN3O4S
Mol. Mass.427.449
SMILESOc1c(C2=Nc3ccccc3S(=O)(=O)N2)c(=O)n(CCC2CC2)c2ccc(F)cc12 |t:3|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: