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TargetHepatitis C virus NS5B RNA-dependent RNA polymerase
LigandBDBM50181656
Substrate/Competitorn/a
Meas. Tech.ChEMBL_330651
IC50 90±n/a nM
Citation Tedesco RShaw ANBambal RChai DConcha NODarcy MGDhanak DFitch DMGates AGerhardt WGHalegoua DLHan CHofmann GAJohnston VKKaura ACLiu NKeenan RMLin-Goerke JSarisky RTWiggall KJZimmerman MNDuffy KJ 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem 49:971-83 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Hepatitis C virus NS5B RNA-dependent RNA polymerase
Name:Hepatitis C virus NS5B RNA-dependent RNA polymerase
Synonyms:NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50181656
n/a
NameBDBM50181656
Synonyms:1-(2-cyclopropylethyl)-3-(1,1-dioxo-1,4-dihydrobenzo[1,2,4]thiadiazin-3-yl)-8-fluoro-4-hydroxy-1H-quinolin-2-one | CHEMBL383170
TypeSmall organic molecule
Emp. Form.C21H18FN3O4S
Mol. Mass.427.449
SMILESOc1c(C2=Nc3ccccc3S(=O)(=O)N2)c(=O)n(CCC2CC2)c2c(F)cccc12 |t:3|
Structure
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