| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50181629 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_330651 (CHEMBL867029) |
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| IC50 | 105±n/a nM |
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| Citation |  Tedesco, R; Shaw, AN; Bambal, R; Chai, D; Concha, NO; Darcy, MG; Dhanak, D; Fitch, DM; Gates, A; Gerhardt, WG; Halegoua, DL; Han, C; Hofmann, GA; Johnston, VK; Kaura, AC; Liu, N; Keenan, RM; Lin-Goerke, J; Sarisky, RT; Wiggall, KJ; Zimmerman, MN; Duffy, KJ 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem49:971-83 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50181629 |
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| n/a |
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| Name | BDBM50181629 |
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| Synonyms: | 5-bromo-3-(1,1-dioxo-1,4-dihydro-1lambda*6*-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1-(3-methyl-butyl)-1H-quinolin-2-one | CHEMBL381529 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H20BrN3O4S |
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| Mol. Mass. | 490.37 |
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| SMILES | CC(C)CCn1c2cccc(Br)c2c(O)c(C2=Nc3ccccc3S(=O)(=O)N2)c1=O |t:17| |
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| Structure | 
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