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TargetBcl-2-like protein 1
LigandBDBM50181894
Substrate/Competitorn/a
Meas. Tech.ChEMBL_332732 (CHEMBL859056)
EC50 4200±n/a nM
Citation Wendt, MDShen, WKunzer, AMcClellan, WJBruncko, MOost, TKDing, HJoseph, MKZhang, HNimmer, PMNg, SCShoemaker, ARPetros, AMOleksijew, AMarsh, KBauch, JOltersdorf, TBelli, BAMartineau, DFesik, SWRosenberg, SHElmore, SW Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo. J Med Chem49:1165-81 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Bcl-2-like protein 1
Name:Bcl-2-like protein 1
Synonyms:Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:26039.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50181894
n/a
NameBDBM50181894
Synonyms:CHEMBL378820 | N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-4-((S)-3-morpholin-4-yl-1-phenylsulfanylmethylpropylamino)-3-nitrobenzenesulfonamide
TypeSmall organic molecule
Emp. Form.C34H43N5O6S2
Mol. Mass.681.865
SMILESCC1(C)CCN(CC1)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccc(N[C@@H](CCN2CCOCC2)CSc2ccccc2)c(c1)[N+]([O-])=O
Structure
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