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TargetApoptosis regulator Bcl-2
LigandBDBM50181880
Substrate/Competitorn/a
Meas. Tech.ChEMBL_332728
Ki 92±n/a nM
Citation Wendt MDShen WKunzer AMcClellan WJBruncko MOost TKDing HJoseph MKZhang HNimmer PMNg SCShoemaker ARPetros AMOleksijew AMarsh KBauch JOltersdorf TBelli BAMartineau DFesik SWRosenberg SHElmore SW Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo. J Med Chem 49:1165-81 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM50181880
n/a
NameBDBM50181880
Synonyms:4-((R)-4-dimethylamino-1-phenylsulfanylmethylbutylamino)-N-[4-(4,4-dimethylpiperidin-1-yl)benzoyl]-3-nitrobenzenesulfonamide | CHEMBL380502
TypeSmall organic molecule
Emp. Form.C33H43N5O5S2
Mol. Mass.653.855
SMILESCN(C)CCC[C@H](CSc1ccccc1)Nc1ccc(cc1[N+]([O-])=O)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(C)(C)CC1
Structure
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