| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA polymerase beta |
|---|
| Ligand | BDBM50181926 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_345624 (CHEMBL859712) |
|---|
| IC50 | >10000±n/a nM |
|---|
| Citation |  Ishida, T; Suzuki, T; Hirashima, S; Mizutani, K; Yoshida, A; Ando, I; Ikeda, S; Adachi, T; Hashimoto, H Benzimidazole inhibitors of hepatitis C virus NS5B polymerase: identification of 2-[(4-diarylmethoxy)phenyl]-benzimidazole. Bioorg Med Chem Lett16:1859-63 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA polymerase beta |
|---|
| Name: | DNA polymerase beta |
|---|
| Synonyms: | DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 38188.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 335 |
|---|
| Sequence: | MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAK
KLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIK
TLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGS
FRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQ
LPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRP
LGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
|
|
|
|---|
| BDBM50181926 |
|---|
| n/a |
|---|
| Name | BDBM50181926 |
|---|
| Synonyms: | 2-{4-[Bis-(4-dimethylcarbamoyl-phenyl)-methoxy]-2-fluoro-phenyl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid | CHEMBL203449 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C39H39FN4O5 |
|---|
| Mol. Mass. | 662.7492 |
|---|
| SMILES | CN(C)C(=O)c1ccc(cc1)C(Oc1ccc(-c2nc3cc(ccc3n2C2CCCCC2)C(O)=O)c(F)c1)c1ccc(cc1)C(=O)N(C)C |
|---|
| Structure | 
|
|---|
Search and Browse
