| Reaction Details |
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 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
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| Ligand | BDBM50181958 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_347313 (CHEMBL865646) |
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| IC50 | 88±n/a nM |
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| Citation |  Evans, KA; Chai, D; Graybill, TL; Burton, G; Sarisky, RT; Lin-Goerke, J; Johnston, VK; Rivero, RA An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. Bioorg Med Chem Lett16:2205-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| RNA-directed RNA polymerase |
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| Name: | RNA-directed RNA polymerase |
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| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
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| Type: | Protein |
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| Mol. Mass.: | 25173.95 |
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| Organism: | Hepatitis C virus |
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| Description: | Q8JXU8 |
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| Residue: | 229 |
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| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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| BDBM50181958 |
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| n/a |
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| Name | BDBM50181958 |
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| Synonyms: | (S)-1-benzyl-5-sec-butyl-3-(1,1-dioxo-1,4-dihydro-1-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one | CHEMBL205579 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H23N3O4S |
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| Mol. Mass. | 425.501 |
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| SMILES | CCC(C)[C@@H]1N(Cc2ccccc2)C(=O)C(C1=O)C1=Nc2ccccc2S(=O)(=O)N1 |t:20| |
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| Structure | 
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