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TargetRNA-directed RNA polymerase
LigandBDBM50181954
Substrate/Competitorn/a
Meas. Tech.ChEMBL_347313 (CHEMBL865646)
IC50 1.7±n/a nM
Citation Evans, KAChai, DGraybill, TLBurton, GSarisky, RTLin-Goerke, JJohnston, VKRivero, RA An efficient, asymmetric solid-phase synthesis of benzothiadiazine-substituted tetramic acids: potent inhibitors of the hepatitis C virus RNA-dependent RNA polymerase. Bioorg Med Chem Lett16:2205-8 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
RNA-directed RNA polymerase
Name:RNA-directed RNA polymerase
Synonyms:Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:Protein
Mol. Mass.:25173.95
Organism:Hepatitis C virus
Description:Q8JXU8
Residue:229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50181954
n/a
NameBDBM50181954
Synonyms:(S)-5-tert-butyl-1-(3,3-dimethyl-butyl)-3-(1,1-dioxo-1,4-dihydro-1-benzo[1,2,4]thiadiazin-3-yl)-4-hydroxy-1,5-dihydro-pyrrol-2-one | CHEMBL204350
TypeSmall organic molecule
Emp. Form.C21H29N3O4S
Mol. Mass.419.538
SMILESCC(C)(C)CCN1[C@H](C(=O)C(C1=O)C1=Nc2ccccc2S(=O)(=O)N1)C(C)(C)C |t:14|
Structure
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