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TargetTumor necrosis factor receptor superfamily member 16
LigandBDBM50182020
Substrate/Competitorn/a
Meas. Tech.ChEMBL_346884 (CHEMBL861548)
Ki>10000±n/a nM
Citation Prabhakaran, JParsey, RVMajo, VJHsiung, SCMilak, MSTamir, HSimpson, NRVan Heertum, RLMann, JJDileep Kumar, JS Synthesis, in vitro and in vivo evaluation of [O-methyl-11C] 2-{4-[4-(3-methoxyphenyl)piperazin-1-yl]-butyl}-4-methyl-2H-[1,2,4]-triazine-3,5-dione: a novel agonist 5-HT1A receptor PET ligand. Bioorg Med Chem Lett16:2101-4 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tumor necrosis factor receptor superfamily member 16
Name:Tumor necrosis factor receptor superfamily member 16
Synonyms:CD_antigen=CD271 | Gp80-LNGFR | Low affinity neurotrophin receptor p75NTR | Low-affinity nerve growth factor receptor | NGF receptor | NGFR | TNFRSF16 | TNR16_HUMAN | Tumor necrosis factor receptor superfamily member 16 | p75 ICD
Type:PROTEIN
Mol. Mass.:45159.83
Organism:Homo sapiens (Human)
Description:ChEMBL_346884
Residue:427
Sequence:
MGAGATGRAMDGPRLLLLLLLGVSLGGAKEACPTGLYTHSGECCKACNLGEGVAQPCGAN
QTVCEPCLDSVTFSDVVSATEPCKPCTECVGLQSMSAPCVEADDAVCRCAYGYYQDETTG
RCEACRVCEAGSGLVFSCQDKQNTVCEECPDGTYSDEANHVDPCLPCTVCEDTERQLREC
TRWADAECEEIPGRWITRSTPPEGSDSTAPSTQEPEAPPEQDLIASTVAGVVTTVMGSSQ
PVVTRGTTDNLIPVYCSILAAVVVGLVAYIAFKRWNSCKQNKQGANSRPVNQTPPPEGEK
LHSDSGISVDSQSLHDQQPHTQTASGQALKGDGGLYSSLPPAKREEVEKLLNGSAGDTWR
HLAGELGYQPEHIDSFTHEACPVRALLASWATQDSATLDALLAALRRIQRADLVESLCSE
STATSPV
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  Blast E-value cutoff:
BDBM50182020
n/a
NameBDBM50182020
Synonyms:2-(4-(4-(3-methoxyphenyl)piperazin-1-yl)butyl)-4-methyl-1,2,4-triazine-3,5(2H,4H)-dione | CHEMBL426317
TypeSmall organic molecule
Emp. Form.C19H27N5O3
Mol. Mass.373.4494
SMILESCOc1cccc(c1)N1CCN(CCCCn2ncc(=O)n(C)c2=O)CC1
Structure
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