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TargetHLA class II histocompatibility antigen gamma chain
LigandBDBM50182110
Substrate/Competitorn/a
Meas. Tech.ChEMBL_347360 (CHEMBL865649)
IC50 950±n/a nM
Citation Grice, CATays, KKhatuya, HGustin, DJButler, CRWei, JSehon, CASun, SGu, YJiang, WThurmond, RLKarlsson, LEdwards, JP The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors. Bioorg Med Chem Lett16:2209-12 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
HLA class II histocompatibility antigen gamma chain
Name:HLA class II histocompatibility antigen gamma chain
Synonyms:CD74 | DHLAG | HG2A_HUMAN | HLA-DR antigens-associated invariant chain
Type:PROTEIN
Mol. Mass.:33525.85
Organism:Homo sapiens (Human)
Description:ChEMBL_347360
Residue:296
Sequence:
MHRRRSRSCREDQKPVMDDQRDLISNNEQLPMLGRRPGAPESKCSRGALYTGFSILVTLL
LAGQATTAYFLYQQQGRLDKLTVTSQNLQLENLRMKLPKPPKPVSKMRMATPLLMQALPM
GALPQGPMQNATKYGNMTEDHVMHLLQNADPLKVYPPLKGSFPENLRHLKNTMETIDWKV
FESWMHHWLLFEMSRHSLEQKPTDAPPKVLTKCQEEVSHIPAVHPGSFRPKCDENGNYLP
LQCYGSIGYCWCVFPNGTEVPNTRSRGHHNCSESLELEDPSSGLGVTKQDLGPVPM
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  Blast E-value cutoff:
BDBM50182110
n/a
NameBDBM50182110
Synonyms:4-(1-(3-(5-(methylsulfonyl)-3-(4-(trifluoromethyl)phenyl)-4,5,6,7-tetrahydropyrazolo[4,3-c]pyridin-1-yl)propyl)piperidin-4-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one | CHEMBL204525
TypeSmall organic molecule
Emp. Form.C30H34F3N5O4S
Mol. Mass.617.682
SMILESCS(=O)(=O)N1CCc2c(C1)c(nn2CCCN1CCC(CC1)N1C(=O)COc2ccccc12)-c1ccc(cc1)C(F)(F)F
Structure
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