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TargetComplement C1s subcomponent
LigandBDBM50182181
Substrate/Competitorn/a
Meas. Tech.ChEBML_347235
Ki 170±n/a nM
Citation Subasinghe, NLTravins, JMAli, FHuang, HBallentine, SKMarugán, JJKhalil, EHufnagel, HRBone, RFDesJarlais, RLCrysler, CSNinan, NCummings, MDMolloy, CJTomczuk, BE A novel series of arylsulfonylthiophene-2-carboxamidine inhibitors of the complement component C1s. Bioorg Med Chem Lett16:2200-4 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Complement C1s subcomponent
Name:Complement C1s subcomponent
Synonyms:C1 esterase | C1S | C1S_HUMAN | Complement C1s | Complement C1s subcomponent | Complement C1s subcomponent heavy chain | Complement C1s subcomponent light chain | Complement component 1 subcomponent s | Trypsin | complement component 1, s subcomponent
Type:Protein
Mol. Mass.:76657.91
Organism:Homo sapiens (Human)
Description:P09871
Residue:688
Sequence:
MWCIVLFSLLAWVYAEPTMYGEILSPNYPQAYPSEVEKSWDIEVPEGYGIHLYFTHLDIE
LSENCAYDSVQIISGDTEEGRLCGQRSSNNPHSPIVEEFQVPYNKLQVIFKSDFSNEERF
TGFAAYYVATDINECTDFVDVPCSHFCNNFIGGYFCSCPPEYFLHDDMKNCGVNCSGDVF
TALIGEIASPNYPKPYPENSRCEYQIRLEKGFQVVVTLRREDFDVEAADSAGNCLDSLVF
VAGDRQFGPYCGHGFPGPLNIETKSNALDIIFQTDLTGQKKGWKLRYHGDPMPCPKEDTP
NSVWEPAKAKYVFRDVVQITCLDGFEVVEGRVGATSFYSTCQSNGKWSNSKLKCQPVDCG
IPESIENGKVEDPESTLFGSVIRYTCEEPYYYMENGGGGEYHCAGNGSWVNEVLGPELPK
CVPVCGVPREPFEEKQRIIGGSDADIKNFPWQVFFDNPWAGGALINEYWVLTAAHVVEGN
REPTMYVGSTSVQTSRLAKSKMLTPEHVFIHPGWKLLEVPEGRTNFDNDIALVRLKDPVK
MGPTVSPICLPGTSSDYNLMDGDLGLISGWGRTEKRDRAVRLKAARLPVAPLRKCKEVKV
EKPTADAEAYVFTPNMICAGGEKGMDSCKGDSGGAFAVQDPNDKTKFYAAGLVSWGPQCG
TYGLYTRVKNYVDWIMKTMQENSTPRED
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50182181
n/a
NameBDBM50182181
Synonyms:4-[7-bromo-3-(2,6-difluoro-benzyl)-3H-benzoimidazole-5-sulfonyl]-5-methylsulfanyl-thiophene-2-carboxamidine | CHEMBL205804
TypeSmall organic molecule
Emp. Form.C20H15BrF2N4O2S3
Mol. Mass.557.455
SMILESCSc1sc(cc1S(=O)(=O)c1cc(Br)c2ncn(Cc3c(F)cccc3F)c2c1)C(N)=N
Structure
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