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TargetProstaglandin G/H synthase 2
LigandBDBM50182338
Substrate/Competitorn/a
Meas. Tech.ChEMBL_344386 (CHEMBL865438)
IC50 10±n/a nM
Citation Cheng, HLundy DeMello, KMLi, JSakya, SMAndo, KKawamura, KKato, TRafka, RJJaynes, BHZiegler, CBStevens, RLund, LAMann, DWKilroy, CHaven, MLNimz, ELDutra, JKLi, CMinich, MLKolosko, NLPetras, CSilvia, AMSeibel, SB Synthesis and SAR of heteroaryl-phenyl-substituted pyrazole derivatives as highly selective and potent canine COX-2 inhibitors. Bioorg Med Chem Lett16:2076-80 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Prostaglandin G/H synthase 2
Name:Prostaglandin G/H synthase 2
Synonyms:Cyclooxygenase-2 | Prostaglandin G/H synthase-2
Type:PROTEIN
Mol. Mass.:68982.35
Organism:Canis familiaris
Description:ChEMBL_344386
Residue:604
Sequence:
MLARALVLCAALAVVRAANPCCSHPCQNQGICMSTGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLYLKPTPNTVHYILTHFKGVWNIVNNIPFLRNTIMKYVLTSRSHLIESPPTYNVNY
GYKSWEAFSNLSYYTRALPPVPDDCPTPMGVKGKKELPDSKEIVEKFLLRRKFIPDPQGT
NMMFAFFAQHFTHQFFKTDHKRGPAFTKGLGHGVDLNHVYGETLDRQHKLRLFKDGKMKY
QVIDGEVYPPTVKDTQVEMIYPPHVPEHLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIAAEFNTLYHWHPLLPDTLQIDDQEYNFQQFIYNNSILLEHGLTQFVESFSRQIAGRV
AGGRNVPAAVQQVAKASIDQSRQMKYQSLNEYRKRFRLKPYTSFEELTGEKEMAAGLEAL
YGDIDAMELYPALLVEKPRPDAIFGETMVEMGAPFSLKGLMGNPICSPDYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTAFSVQDGQLTKTVTINASSSHSGLDDINPTVLLKER
STEL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50182338
n/a
NameBDBM50182338
Synonyms:2-(5-(4-(furan-2-yl)-3-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)-5-(methylsulfonyl)pyridine | CHEMBL378649
TypeSmall organic molecule
Emp. Form.C21H16F3N3O3S
Mol. Mass.447.43
SMILESCc1cc(ccc1-c1ccco1)-c1cc(nn1-c1ccc(cn1)S(C)(=O)=O)C(F)(F)F
Structure
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