| Reaction Details |
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 | Report a problem with these data |
| Target | Matrix metalloproteinase-14 |
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| Ligand | BDBM50182403 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_350096 (CHEMBL865077) |
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| Ki | 1200±n/a nM |
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| Citation |  Thompson, LA; Liauw, AY; Ramanjulu, MM; Kasireddy-Polam, P; Mercer, SE; Maduskuie, TP; Glicksman, M; Roach, AH; Meredith, JE; Liu, RQ; Combs, AP; Higaki, JN; Cordell, B; Seiffert, D; Zaczek, RC; Robertson, DW; Olson, RE Synthesis and evaluation of succinoyl-caprolactam gamma-secretase inhibitors. Bioorg Med Chem Lett16:2357-63 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Matrix metalloproteinase-14 |
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| Name: | Matrix metalloproteinase-14 |
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| Synonyms: | MMP-14 | MMP-X1 | MMP14 | MMP14_HUMAN | MT-MMP 1 | MT1-MMP | MT1MMP | MTMMP1 | Matrix Metalloproteinase-14 (MMP-14) | Matrix metalloproteinase 14 | Matrix metalloproteinase-14 | Matrix metalloproteinase-14 (MMP14) | Membrane-type matrix metalloproteinase 1 | Membrane-type-1 matrix metalloproteinase |
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| Type: | Protein |
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| Mol. Mass.: | 65900.19 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P50281 |
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| Residue: | 582 |
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| Sequence: | MSPAPRPPRCLLLPLLTLGTALASLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSPQS
LSAAIAAMQKFYGLQVTGKADADTMKAMRRPRCGVPDKFGAEIKANVRRKRYAIQGLKWQ
HNEITFCIQNYTPKVGEYATYEAIRKAFRVWESATPLRFREVPYAYIREGHEKQADIMIF
FAEGFHGDSTPFDGEGGFLAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDIFLVAVHE
LGHALGLEHSSDPSAIMAPFYQWMDTENFVLPDDDRRGIQQLYGGESGFPTKMPPQPRTT
SRPSVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKERWFWRVRNNQVMDGYPMPIGQF
WRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRGLPTDKIDAALF
WMPNGKTYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFYKG
NKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGRPDEGTEEETEVIIIEVDEEGGGAVSAA
AVVLPVLLLLLVLAVGLAVFFFRRHGTPRRLLYCQRSLLDKV
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| BDBM50182403 |
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| n/a |
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| Name | BDBM50182403 |
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| Synonyms: | (2R,3S)-N1-((S)-1-(3-phenoxybenzyl)-2-oxoazepan-3-yl)-N4-hydroxy-2-isobutyl-3-propylsuccinamide | (2S,3R)-N1-hydroxy-3-isobutyl-N4-((S)-2-oxo-1-(3-phenoxybenzyl)azepan-3-yl)-2-propylsuccinamide | CHEMBL204357 | SR-973 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H41N3O5 |
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| Mol. Mass. | 523.6636 |
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| SMILES | CCC[C@@H]([C@@H](CC(C)C)C(=O)N[C@H]1CCCCN(Cc2cccc(Oc3ccccc3)c2)C1=O)C(=O)NO |
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| Structure | 
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