| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50182460 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_333384 (CHEMBL859128) |
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| Ki | 1.8±n/a nM |
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| Citation |  Wood, MR; Schirripa, KM; Kim, JJ; Wan, BL; Murphy, KL; Ransom, RW; Chang, RS; Tang, C; Prueksaritanont, T; Detwiler, TJ; Hettrick, LA; Landis, ER; Leonard, YM; Krueger, JA; Lewis, SD; Pettibone, DJ; Freidinger, RM; Bock, MG Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine. Application to the design of novel bradykinin B1 receptor antagonists. J Med Chem49:1231-4 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50182460 |
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| n/a |
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| Name | BDBM50182460 |
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| Synonyms: | CHEMBL201041 | methyl 4'-[({[1-({[5-(trifluoromethyl)pyridin-3-yl]carbonyl}amino)cyclopropyl]-carbonyl}amino)methyl]biphenyl-2-carboxylate |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22F3N3O4 |
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| Mol. Mass. | 497.4658 |
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| SMILES | COC(=O)c1ccccc1-c1ccc(CNC(=O)C2(CC2)NC(=O)c2cncc(c2)C(F)(F)F)cc1 |
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| Structure | 
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