Ki Summary

Reaction Details

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Target

GABA receptor alpha-1/beta-3/gamma-2 subunit

Ligand

BDBM50182468

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_333414

0.15±n/a nM

Citation

Russell MG; Carling RW; Street LJ; Hallett DJ; Goodacre S; Mezzogori E; Reader M; Cook SM; Bromidge FA; Newman R; Smith AJ; Wafford KA; Marshall GR; Reynolds DS; Dias R; Ferris P; Stanley J; Lincoln R; Tye SJ; Sheppard WF; Sohal B; Pike A; Dominguez M; Atack JR; Castro JL Discovery of imidazo[1,2-b][1,2,4]triazines as GABA(A) alpha2/3 subtype selective agonists for the treatment of anxiety. J Med Chem 49:1235-8 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

GABA receptor alpha-1/beta-3/gamma-2 subunit

Name:

GABA receptor alpha-1/beta-3/gamma-2 subunit

Synonyms:

GABA-A receptor; alpha-1/beta-3/gamma-2

Type:

n/a

Mol. Mass.:

n/a

Description:

ASSAY_ID of EBI is 312

Components:

This complex has 3 components.

Component 1

Name:

Gamma-aminobutyric acid receptor subunit alpha-1/ beta-1

Synonyms:

Type:

Protein

Mol. Mass.:

51817.35

Organism:

Homo sapiens (Human)

Description:

P14867

Residue:

456

Sequence:

MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG
LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC
PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM
TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP
LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID
RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ

Component 2

Name:

GABA A receptor alpha-2/beta-2/gamma-2

Synonyms:

GABA(A) receptor subunit gamma-2 | Gamma-aminobutyric acid receptor subunit gamma-2

Type:

PROTEIN

Mol. Mass.:

54172.74

Organism:

Homo sapiens (Human)

Description:

EBI_217

Residue:

467

Sequence:

MSSPNIWSTGSSVYSTPVFSQKMTVWILLLLSLYPGFTSQKSDDDYEDYASNKTWVLTPK
VPEGDVTVILNNLLEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQT
WYDRRLKFNSTIKVLRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLY
TLRLTIDAECQLQLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQF
SFVGLRNTTEVVKTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDA
VPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFV
SNRKPSKDKDKKKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCC
FEDCRTGAWRHGRIHIRIAKMDSYARIFFPTAFCLFNLVYWVSYLYL

Component 3

Name:

Gamma-aminobutyric acid receptor subunit alpha-3/beta-3

Synonyms:

GABA receptor beta-3 subunit | GABA-A receptor | agonist GABA site

Type:

PROTEIN

Mol. Mass.:

54130.51

Organism:

Homo sapiens (Human)

Description:

ChEMBL_448071

Residue:

473

Sequence:

MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPP
VCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPD
TYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIE
SYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLK
RNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKI
PYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNR
VDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRS
LPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN

BDBM50182468

n/a

Name

BDBM50182468

Synonyms:

4,6,2'-Trifluoro-5'-[3-(1-hydroxy-1-methyl-ethyl)-imidazo[1,2-b][1,2,4]triazin-7-yl]-biphenyl-2-carbonitrile | CHEMBL202343

Type

Small organic molecule

Emp. Form.

C21H14F3N5O

Mol. Mass.

409.364

SMILES

CC(C)(O)c1cnn2c(cnc2n1)-c1ccc(F)c(c1)-c1c(F)cc(F)cc1C#N |(2.53,2.37,;3.87,1.59,;3.1,.25,;4.63,2.93,;5.21,.82,;5.21,-.72,;6.56,-1.49,;7.88,-.72,;9.34,-1.19,;10.25,.05,;9.35,1.3,;7.88,.82,;6.55,1.59,;9.75,-2.68,;8.67,-3.78,;9.07,-5.25,;10.56,-5.64,;10.96,-7.13,;11.65,-4.56,;11.23,-3.07,;13.13,-4.94,;13.54,-6.42,;12.46,-7.51,;15.03,-6.8,;16.11,-5.71,;17.63,-6.09,;15.69,-4.23,;14.22,-3.84,;13.82,-2.34,;13.42,-.84,)|

Structure