| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent noradrenaline transporter |
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| Ligand | BDBM50183154 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_355136 (CHEMBL853189) |
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| Ki | 6.1±n/a nM |
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| Citation |  Boot, JR; Boulet, SL; Clark, BP; Cases-Thomas, MJ; Delhaye, L; Diker, K; Fairhurst, J; Findlay, J; Gallagher, PT; Gilmore, J; Harris, JR; Masters, JJ; Mitchell, SN; Naik, M; Simmonds, RG; Smith, SM; Richards, SJ; Timms, GH; Whatton, MA; Wolfe, CN; Wood, VA N-Alkyl-N-arylmethylpiperidin-4-amines: novel dual inhibitors of serotonin and norepinephrine reuptake. Bioorg Med Chem Lett16:2714-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent noradrenaline transporter |
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| Name: | Sodium-dependent noradrenaline transporter |
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| Synonyms: | Monoamine transporter | NAT1 | NET | NET1 | Noradrenaline Transporter (NET) | Norepinephrine Transporter (NET) | Norepinephrine transporter protein (NET) | SC6A2_HUMAN | SLC6A2 | SLC6A5 | Sodium-dependent noradrenaline transporter (NET) | Solute carrier family 6 member 2 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 69337.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P23975 |
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| Residue: | 617 |
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| Sequence: | MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
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| BDBM50183154 |
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| n/a |
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| Name | BDBM50183154 |
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| Synonyms: | CHEMBL207067 | CHEMBL207214 | N-(4-fluoro-2-(trifluoromethyl)benzyl)-N-(cyclopropylmethyl)piperidin-4-amine tartaric acid salt |
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| Type | Small organic molecule |
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| Emp. Form. | C17H22F4N2 |
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| Mol. Mass. | 330.3636 |
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| SMILES | Fc1ccc(CN(CC2CC2)C2CCNCC2)c(c1)C(F)(F)F |
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| Structure | 
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