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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Reverse transcriptase/RNaseH | ||
| Ligand | BDBM50183204 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_355438 (CHEMBL868998) | ||
| IC50 | 54±n/a nM | ||
| Citation |  Muraglia, E; Kinzel, OD; Laufer, R; Miller, MD; Moyer, G; Munshi, V; Orvieto, F; Palumbi, MC; Pescatore, G; Rowley, M; Williams, PD; Summa, V Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant. Bioorg Med Chem Lett16:2748-52 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Reverse transcriptase/RNaseH | |||
| Name: | Reverse transcriptase/RNaseH | ||
| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 65229.15 | ||
| Organism: | Human immunodeficiency virus 1 | ||
| Description: | ChEMBL_1473730 | ||
| Residue: | 566 | ||
| Sequence: |
| ||
| BDBM50183204 | |||
| n/a | |||
| Name | BDBM50183204 | ||
| Synonyms: | CHEMBL208057 | N-(2-methyl-4-sulfamoyl-phenyl)-2-[1-(2,4,6-trimethyl-phenyl)-1H-tetrazol-5-ylsulfanyl]-acetamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C19H22N6O3S2 | ||
| Mol. Mass. | 446.546 | ||
| SMILES | Cc1cc(C)c(c(C)c1)-n1nnnc1SCC(=O)Nc1ccc(cc1C)S(N)(=O)=O |(-6.98,-13.11,;-6.65,-11.6,;-7.79,-10.56,;-7.46,-9.06,;-8.59,-8.02,;-5.99,-8.59,;-4.85,-9.62,;-3.39,-9.15,;-5.18,-11.14,;-5.67,-7.08,;-6.69,-5.93,;-5.92,-4.6,;-4.41,-4.92,;-4.26,-6.46,;-2.93,-7.23,;-1.59,-6.46,;-.26,-7.23,;-.26,-8.77,;1.08,-6.47,;2.41,-7.24,;2.4,-8.78,;3.73,-9.55,;5.07,-8.78,;5.07,-7.24,;3.73,-6.47,;3.73,-4.93,;6.4,-9.55,;7.73,-10.32,;5.63,-10.89,;7.18,-8.22,)| | ||
| Structure | 
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