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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Reverse transcriptase/RNaseH | ||
| Ligand | BDBM50183209 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_355438 (CHEMBL868998) | ||
| IC50 | 22±n/a nM | ||
| Citation |  Muraglia, E; Kinzel, OD; Laufer, R; Miller, MD; Moyer, G; Munshi, V; Orvieto, F; Palumbi, MC; Pescatore, G; Rowley, M; Williams, PD; Summa, V Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant. Bioorg Med Chem Lett16:2748-52 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Reverse transcriptase/RNaseH | |||
| Name: | Reverse transcriptase/RNaseH | ||
| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 65229.15 | ||
| Organism: | Human immunodeficiency virus 1 | ||
| Description: | ChEMBL_1473730 | ||
| Residue: | 566 | ||
| Sequence: |
| ||
| BDBM50183209 | |||
| n/a | |||
| Name | BDBM50183209 | ||
| Synonyms: | CHEMBL204993 | N-(2-chloro-4-nitrophenyl)-2-(1-mesityl-1H-tetrazol-5-ylthio)acetamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H17ClN6O3S | ||
| Mol. Mass. | 432.884 | ||
| SMILES | Cc1cc(C)c(c(C)c1)-n1nnnc1SCC(=O)Nc1ccc(cc1Cl)[N+]([O-])=O |(14.87,-48.33,;15.2,-46.83,;14.07,-45.79,;14.4,-44.28,;13.26,-43.24,;15.86,-43.81,;17,-44.85,;18.47,-44.38,;16.67,-46.36,;16.19,-42.31,;15.16,-41.15,;15.94,-39.82,;17.44,-40.15,;17.6,-41.68,;18.93,-42.45,;20.26,-41.69,;21.6,-42.46,;21.59,-44,;22.93,-41.69,;24.26,-42.46,;24.26,-44,;25.59,-44.78,;26.92,-44.01,;26.92,-42.46,;25.59,-41.7,;25.59,-40.16,;28.26,-44.78,;28.26,-46.32,;29.59,-44.01,)| | ||
| Structure | 
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