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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Reverse transcriptase/RNaseH | ||
| Ligand | BDBM50183197 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_355438 (CHEMBL868998) | ||
| IC50 | 31±n/a nM | ||
| Citation |  Muraglia, E; Kinzel, OD; Laufer, R; Miller, MD; Moyer, G; Munshi, V; Orvieto, F; Palumbi, MC; Pescatore, G; Rowley, M; Williams, PD; Summa, V Tetrazole thioacetanilides: potent non-nucleoside inhibitors of WT HIV reverse transcriptase and its K103N mutant. Bioorg Med Chem Lett16:2748-52 (2006) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Reverse transcriptase/RNaseH | |||
| Name: | Reverse transcriptase/RNaseH | ||
| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 65229.15 | ||
| Organism: | Human immunodeficiency virus 1 | ||
| Description: | ChEMBL_1473730 | ||
| Residue: | 566 | ||
| Sequence: |
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| BDBM50183197 | |||
| n/a | |||
| Name | BDBM50183197 | ||
| Synonyms: | CHEMBL205999 | N-(2-iodophenyl)-2-(1-mesityl-1H-tetrazol-5-ylthio)acetamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H18IN5OS | ||
| Mol. Mass. | 479.338 | ||
| SMILES | Cc1cc(C)c(c(C)c1)-n1nnnc1SCC(=O)Nc1ccccc1I |(-7.14,-25.92,;-6.81,-24.42,;-7.95,-23.38,;-7.61,-21.87,;-8.75,-20.83,;-6.15,-21.41,;-5.01,-22.44,;-3.54,-21.97,;-5.34,-23.95,;-5.82,-19.9,;-6.85,-18.75,;-6.07,-17.41,;-4.57,-17.74,;-4.41,-19.27,;-3.08,-20.05,;-1.75,-19.28,;-.41,-20.05,;-.42,-21.59,;.92,-19.28,;2.25,-20.06,;2.25,-21.6,;3.58,-22.37,;4.91,-21.6,;4.91,-20.05,;3.58,-19.29,;3.58,-17.75,)| | ||
| Structure | 
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