| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Malonyl-CoA decarboxylase, mitochondrial |
|---|
| Ligand | BDBM50183316 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_336476 (CHEMBL859660) |
|---|
| IC50 | 1.99±n/a nM |
|---|
| Citation |  Cheng, JF; Chen, M; Wallace, D; Tith, S; Haramura, M; Liu, B; Mak, CC; Arrhenius, T; Reily, S; Brown, S; Thorn, V; Harmon, C; Barr, R; Dyck, JR; Lopaschuk, GD; Nadzan, AM Synthesis and structure-activity relationship of small-molecule malonyl coenzyme A decarboxylase inhibitors. J Med Chem49:1517-25 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Malonyl-CoA decarboxylase, mitochondrial |
|---|
| Name: | Malonyl-CoA decarboxylase, mitochondrial |
|---|
| Synonyms: | DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 55018.37 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_665404 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKT
PAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAA
VLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNG
VLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFF
SHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQG
VELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSEC
KEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVA
NFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQV
LSLVAQFQKNSKL
|
|
|
|---|
| BDBM50183316 |
|---|
| n/a |
|---|
| Name | BDBM50183316 |
|---|
| Synonyms: | CHEMBL202746 | N-methyl-N-phenethyl-4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)benzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C19H17F6NO2 |
|---|
| Mol. Mass. | 405.3342 |
|---|
| SMILES | CN(CCc1ccccc1)C(=O)c1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
