Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50158845 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_337082 (CHEMBL864369) |
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IC50 | 44±n/a nM |
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Citation | Koch, U; Attenni, B; Malancona, S; Colarusso, S; Conte, I; Di Filippo, M; Harper, S; Pacini, B; Giomini, C; Thomas, S; Incitti, I; Tomei, L; De Francesco, R; Altamura, S; Matassa, VG; Narjes, F 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as inhibitors of the hepatitis C virus NS5B polymerase: discovery, SAR, modeling, and mutagenesis. J Med Chem49:1693-705 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50158845 |
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n/a |
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Name | BDBM50158845 |
Synonyms: | 2-(3-(3-(2-chlorobenzyl)ureido)thiophen-2-yl)-5,6-dihydroxypyrimidine-4-carboxylic acid | 2-[3-({[(2-chlorobenzyl)amino]carbonyl}amino)-2-thienyl]-5,6-dihydroxypyrimidine-4-carboxylic acid | 2-{3-[3-(2-Chloro-benzyl)-ureido]-thiophen-2-yl}-5-hydroxy-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid | CHEMBL175882 |
Type | Small organic molecule |
Emp. Form. | C17H13ClN4O5S |
Mol. Mass. | 420.827 |
SMILES | OC(=O)c1nc([nH]c(=O)c1O)-c1sccc1NC(=O)NCc1ccccc1Cl |
Structure |
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