| Reaction Details |
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 | Report a problem with these data |
| Target | Cysteine protease |
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| Ligand | BDBM50183753 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_350622 (CHEMBL869006) |
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| Ki | 900±n/a nM |
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| Citation |  Vicik, R; Hoerr, V; Glaser, M; Schultheis, M; Hansell, E; McKerrow, JH; Holzgrabe, U; Caffrey, CR; Ponte-Sucre, A; Moll, H; Stich, A; Schirmeister, T Aziridine-2,3-dicarboxylate inhibitors targeting the major cysteine protease of Trypanosoma brucei as lead trypanocidal agents. Bioorg Med Chem Lett16:2753-7 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cysteine protease |
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| Name: | Cysteine protease |
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| Synonyms: | Rhodesain |
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| Type: | PROTEIN |
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| Mol. Mass.: | 48425.78 |
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| Organism: | Trypanosoma brucei rhodesiense |
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| Description: | ChEMBL_619861 |
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| Residue: | 450 |
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| Sequence: | MPRTEMVRFVRLPVVLLAMAACLASVALGSLHVEESLEMRFAAFKKKYGKVYKDAKEEAF
RFRAFEENMEQAKIQAAANPYATFGVTPFSDMTREEFRARYRNGASYFAAAQKRLRKTVN
VTTGRAPAAVDWREKGAVTPVKDQGQCGSCWAFSTIGNIEGQWQVAGNPLVSLSEQMLVS
CDTIDFGCGGGLMDNAFNWIVNSNGGNVFTEASYPYVSGNGEQPQCQMNGHEIGAAITDH
VDLPQDEDAIAAYLAENGPLAIAVDATSFMDYNGGILTSCTSEQLDHGVLLVGYNDSSNP
PYWIIKNSWSNMWGEDGYIRIEKGTNQCLMNQAVSSAVVGGPTPPPPPPPPPSATFTQDF
CEGKGCTKGCSHATFPTGECVQTTGVGSVIATCGASNLTQIIYPLSRSCSGLSVPITVPL
DKCIPILIGSVEYHCSTNPPTKAARLVPHQ
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| BDBM50183753 |
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| n/a |
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| Name | BDBM50183753 |
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| Synonyms: | (2S,3S)-1-((S)-1-(2-(tert-butoxycarbonyl)acetyl)pyrrolidine-5-carbonyl)aziridine-2,3-dicarboxylic acid | CHEMBL382431 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H23N3O8 |
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| Mol. Mass. | 385.3691 |
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| SMILES | CC(C)(C)OC(=O)NCC(=O)N1CCC[C@H]1C(=O)N1[C@@H]([C@H]1C(O)=O)C(O)=O |
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| Structure | 
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