Reaction Details |
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Target | Thromboxane A2 receptor |
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Ligand | BDBM50184221 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_364758 (CHEMBL871220) |
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Ki | 2700±n/a nM |
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Citation | Sturino, CF; Lachance, N; Boyd, M; Berthelette, C; Labelle, M; Li, L; Roy, B; Scheigetz, J; Tsou, N; Brideau, C; Cauchon, E; Carriere, MC; Denis, D; Greig, G; Kargman, S; Lamontagne, S; Mathieu, MC; Sawyer, N; Slipetz, D; O'Neill, G; Wang, Z; Zamboni, R; Metters, KM; Young, RN Identification of an indole series of prostaglandin D2 receptor antagonists. Bioorg Med Chem Lett16:3043-8 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Thromboxane A2 receptor |
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Name: | Thromboxane A2 receptor |
Synonyms: | Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta |
Type: | Enyzme |
Mol. Mass.: | 37445.28 |
Organism: | Homo sapiens (Human) |
Description: | P21731 |
Residue: | 343 |
Sequence: | MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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BDBM50184221 |
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n/a |
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Name | BDBM50184221 |
Synonyms: | 2-(4-(4-(methylsulfonyl)benzyl)-5-bromo-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid | CHEMBL210588 |
Type | Small organic molecule |
Emp. Form. | C22H22BrNO6S2 |
Mol. Mass. | 540.447 |
SMILES | CS(=O)(=O)c1ccc(Cn2c3C(CC(O)=O)CCc3c3cc(cc(Br)c23)S(C)(=O)=O)cc1 |
Structure |
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