Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetThromboxane A2 receptor
LigandBDBM50184222
Substrate/Competitorn/a
Meas. Tech.ChEMBL_364758 (CHEMBL871220)
Ki 180±n/a nM
Citation Sturino, CFLachance, NBoyd, MBerthelette, CLabelle, MLi, LRoy, BScheigetz, JTsou, NBrideau, CCauchon, ECarriere, MCDenis, DGreig, GKargman, SLamontagne, SMathieu, MCSawyer, NSlipetz, DO'Neill, GWang, ZZamboni, RMetters, KMYoung, RN Identification of an indole series of prostaglandin D2 receptor antagonists. Bioorg Med Chem Lett16:3043-8 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Thromboxane A2 receptor
Name:Thromboxane A2 receptor
Synonyms:Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:Enyzme
Mol. Mass.:37445.28
Organism:Homo sapiens (Human)
Description:P21731
Residue:343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTR
SSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPL
LLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPG
SWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSE
VEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWN
QILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50184222
n/a
NameBDBM50184222
Synonyms:2-(5-bromo-4-((7-chloroquinolin-2-yl)methyl)-7-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid | CHEMBL207201
TypeSmall organic molecule
Emp. Form.C24H20BrClN2O4S
Mol. Mass.547.849
SMILESCS(=O)(=O)c1cc(Br)c2n(Cc3ccc4ccc(Cl)cc4n3)c3C(CC(O)=O)CCc3c2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: