Ki Summary

Reaction Details

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Target

Melanocortin receptor 4

Ligand

BDBM50184350

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_338133 (CHEMBL867660)

IC50

170±n/a nM

Citation

Mayorov, AV; Cai, M; Chandler, KB; Petrov, RR; Van Scoy, AR; Yu, Z; Tanaka, DK; Trivedi, D; Hruby, VJ Development of cyclic gamma-MSH analogues with selective hMC3R agonist and hMC3R/hMC5R antagonist activities. J Med Chem49:1946-52 (2006) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Melanocortin receptor 4

Name:

Melanocortin receptor 4

Synonyms:

Type:

Enzyme

Mol. Mass.:

36949.50

Organism:

Homo sapiens (Human)

Description:

P32245

Residue:

332

Sequence:

MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY

BDBM50184350

n/a

Name

BDBM50184350

Synonyms:

CHEMBL409144 | c[Nle-Asp-D-Nal(2')-Arg-Trp-Glu]-NH2

Type

Small organic molecule

Emp. Form.

C45H57N11O9

Mol. Mass.

896.0024

SMILES

CCCC[C@@H]1NC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@@H](CC(O)=O)NC1=O)C(N)=O |wU:54.58,39.41,10.66,wD:28.30,14.14,4.3,(-1.99,-36.06,;-1.99,-37.6,;-.9,-38.32,;-.91,-39.84,;.32,-40.55,;2.02,-39.92,;2.01,-38.38,;.68,-37.62,;3.23,-37.6,;3.76,-36.32,;5.28,-36.11,;6.04,-37.44,;6.8,-38.77,;8.29,-38.36,;7.2,-40.26,;8.74,-40.26,;9.51,-41.6,;9.51,-43.14,;10.97,-43.62,;11.87,-42.38,;13.4,-42.23,;14.04,-40.83,;13.14,-39.58,;11.61,-39.73,;10.98,-41.13,;6.26,-41.48,;6.85,-42.9,;8.39,-42.89,;6.45,-44.38,;7.54,-45.47,;9.03,-45.08,;10.11,-46.16,;11.6,-45.76,;12.69,-46.86,;14.18,-46.46,;12.3,-48.35,;5.1,-45.15,;3.78,-44.37,;3.79,-42.82,;2.44,-45.13,;2.44,-46.67,;3.77,-47.44,;5.09,-46.68,;6.43,-47.44,;6.43,-48.99,;7.76,-49.76,;7.76,-51.3,;6.42,-52.08,;5.08,-51.3,;5.09,-49.76,;3.76,-48.98,;1.1,-44.36,;-.23,-45.12,;-.23,-46.66,;-1.55,-44.35,;-2.74,-45.1,;-3.98,-44.45,;-4.03,-43.06,;-5.16,-45.19,;-1.56,-42.82,;-.02,-42.07,;1.2,-42.82,;6.05,-34.77,;5.28,-33.44,;7.59,-34.78,)|

Structure