Reaction Details |
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Target | C-C chemokine receptor type 5 |
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Ligand | BDBM50184399 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_338784 (CHEMBL860618) |
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IC50 | 1.7±n/a nM |
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Citation | Seto, M; Aikawa, K; Miyamoto, N; Aramaki, Y; Kanzaki, N; Takashima, K; Kuze, Y; Iizawa, Y; Baba, M; Shiraishi, M Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety. J Med Chem49:2037-48 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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C-C chemokine receptor type 5 |
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Name: | C-C chemokine receptor type 5 |
Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
Type: | Enzyme |
Mol. Mass.: | 40540.21 |
Organism: | Homo sapiens (Human) |
Description: | P51681 |
Residue: | 352 |
Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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BDBM50184399 |
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n/a |
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Name | BDBM50184399 |
Synonyms: | (S)-(-)-8-{4-[2-(butoxy)ethoxy]phenyl}-1-[(1-methyl-1H-pyrazol-4-yl)methyl]-N-(4-{[(1-propyl-1H-imidazol-5-yl)methyl]-sulfinyl}phenyl)-1,2,3,4-tetrahydro-1-benzazocine-5-carboxamide | CHEMBL204743 |
Type | Small organic molecule |
Emp. Form. | C42H50N6O4S |
Mol. Mass. | 734.949 |
SMILES | CCCCOCCOc1ccc(cc1)-c1ccc2N(Cc3cnn(C)c3)CCCC(=Cc2c1)C(=O)Nc1ccc(cc1)S(=O)Cc1cncn1CCC |w:30.32| |
Structure |
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