| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 20 |
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| Ligand | BDBM50184487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_337604 (CHEMBL861565) |
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| IC50 | 8480±n/a nM |
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| Citation |  Li, HY; Wang, Y; Heap, CR; King, CH; Mundla, SR; Voss, M; Clawson, DK; Yan, L; Campbell, RM; Anderson, BD; Wagner, JR; Britt, K; Lu, KX; McMillen, WT; Yingling, JM Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7. J Med Chem49:2138-42 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 20 |
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| Name: | Mitogen-activated protein kinase kinase kinase 20 |
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| Synonyms: | M3K20_HUMAN | MAP3K20 | MLK7 | MLTK | Mixed lineage kinase 7 | ZAK |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91168.58 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1495629 |
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| Residue: | 800 |
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| Sequence: | MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
SPAKTNKERARGDHRGWRNF
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| BDBM50184487 |
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| n/a |
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| Name | BDBM50184487 |
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| Synonyms: | 4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-1H-benzo[d]imidazol-1-yl)propyl)morpholine | 6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl]-1-(3-morpholin-4-yl-propyl)-1H-benzoimidazole | CHEMBL381532 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H30N6O |
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| Mol. Mass. | 442.556 |
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| SMILES | Cc1cccc(n1)-c1nn2CCCc2c1-c1ccc2ncn(CCCN3CCOCC3)c2c1 |
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| Structure | 
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