| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 20 |
|---|
| Ligand | BDBM21492 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_337604 (CHEMBL861565) |
|---|
| IC50 | 1400±n/a nM |
|---|
| Citation |  Li, HY; Wang, Y; Heap, CR; King, CH; Mundla, SR; Voss, M; Clawson, DK; Yan, L; Campbell, RM; Anderson, BD; Wagner, JR; Britt, K; Lu, KX; McMillen, WT; Yingling, JM Dihydropyrrolopyrazole transforming growth factor-beta type I receptor kinase domain inhibitors: a novel benzimidazole series with selectivity versus transforming growth factor-beta type II receptor kinase and mixed lineage kinase-7. J Med Chem49:2138-42 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 20 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 20 |
|---|
| Synonyms: | M3K20_HUMAN | MAP3K20 | MLK7 | MLTK | Mixed lineage kinase 7 | ZAK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 91168.58 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1495629 |
|---|
| Residue: | 800 |
|---|
| Sequence: | MSSLGASFVQIKFDDLQFFENCGGGSFGSVYRAKWISQDKEVAVKKLLKIEKEAEILSVL
SHRNIIQFYGVILEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHY
LHMEAPVKVIHRDLKSRNVVIAADGVLKICDFGASRFHNHTTHMSLVGTFPWMAPEVIQS
LPVSETCDTYSYGVVLWEMLTREVPFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLH
QCWEADAKKRPSFKQIISILESMSNDTSLPDKCNSFLHNKAEWRCEIEATLERLKKLERD
LSFKEQELKERERRLKMWEQKLTEQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAE
MSVYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPL
IKDSGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNT
NLPDAEILKMTKPPFVMEKWIVGIAKSQTVECTVTYESDVRTPKSTKHVHSIQWSRTKPQ
DEVKAVQLAIQTLFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSP
FFSHFDGQDSYAAAVRRPQVPIKYQQITPVNQSRSSSPTQYGLTKNFSSLHLNSRDSGFS
SGNTDTSSERGRYSDRSRNKYGRGSISLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQS
ALNPHQSPDFKRSPRDLHQPNTIPGMPLHPETDSRASEEDSKVSEGGWTKVEYRKKPHRP
SPAKTNKERARGDHRGWRNF
|
|
|
|---|
| BDBM21492 |
|---|
| n/a |
|---|
| Name | BDBM21492 |
|---|
| Synonyms: | 4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CHEMBL261454 | LY364947 | US11759530, Compound Table1.1 | US9138393, LY-364947 | US9144538, LY-364947 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H12N4 |
|---|
| Mol. Mass. | 272.304 |
|---|
| SMILES | c1[nH]nc(c1-c1ccnc2ccccc12)-c1ccccn1 |
|---|
| Structure | 
|
|---|
Search and Browse
